Cannabis may help combat cancer

Cannabis against Cancer

 

While there is still no real cure for cancer, every day researchers move a step closer to finding that cure. Twenty-five-year old Natalya Kogan, a Ph.D. candidate at the Hebrew University of Jerusalem, working under the supervision of Prof. Raphael Meshulam, recently proved that extract from the cannabis plant is able to help heal cancer within the organism.

Kogan, who immigrated from the Ukraine 10 years ago, developed a new compound known as guinniodic cannabinoids, which is similar to several anti-cancer medications such as Daunomycin. Whereas Daunomycin produces negative side effects in the heart, Kogan’s tests have proven the new compound to be much less harmful, even reducing the volume of cancer, which it did during animal testing.

What makes guinniodic cannabinoids compound so different is that it forms a complex with the enzyme Topoisomerase II, which is responsible for mitosis (when two new nuclei form with the same number of chromosomes as the nucleus from which they’re formed). This specifically stops the division of cells and growth of the tissues, as compared to most of today’s anti-cancer substances that are less selective in their action. These substances also reduce the blood supply to the cancer tissue.

While Kogan continues her research to discover mechanisms and modes of action for these substances, in the interim the substances themselves have a high potential for future anticancer medications. Kogan received the Kaye-Innovation Prize from the university for her research

 Marijuana Unlikely to Cause Head, Neck, or Lung Cancer

By Peggy Peck
WebMD Medical News

May 8, 2000 (Boston) -- Marijuana, unlike tobacco and alcohol, does not appear to cause head, neck, or lung cancer, says a researcher from Johns Hopkins Medical School in Baltimore who presented findings from a study here recently at a meeting of internal medicine physicians.

There has been an ongoing debate about whether marijuana is as dangerous as tobacco in terms of cancer development. Daniel E. Ford, MD, tried to sort out the evidence by the lifestyles -- including marijuana, tobacco, and alcohol use -- of 164 persons who were newly diagnosed with head, neck, or lung cancer compared to a group of 526 healthy persons living in the same area. The average age of patients was 49, while the average age of the healthy volunteers was 44. The cancer patients were all treated at four Baltimore-area hospitals, and the "controls" (healthy comparison group) were selected from a large group of people living in the Baltimore area who had been participating in an ongoing study. Ford tells WebMD that he wanted to find out whether the cancer patients were more likely to smoke marijuana or tobacco or to drink than were the healthy volunteers.

According to Ford, he thought he would find an association between marijuana use and cancer, but "that the association would fall away when we corrected for tobacco use. That was not the case. The association was never there." And that surprised him because of the way marijuana is smoked: deep inhalations, with the smoke held in for effect. "It seemed natural that there would be some connection," he tells WebMD.

Based on these findings, Ford says that cancer prevention efforts should "remain focused on tobacco and alcohol, two known carcinogens."

He says his conclusions differ from another study reported recently. That study linked marijuana use to cancer, but Ford says he thinks the difference can be explained by the fact that the healthy volunteers in that study "had very, very low use of marijuana." That contrasts to his study, in which "we were investigating the effect of marijuana as it is commonly used in the community," he says. Use of all substances -- tobacco, alcohol, and marijuana -- was common among both cancer patients and controls, he says.

"We attempted to assess both lifetime and current use of substances," he says. Participants were also asked to differentiate between use of marijuana cigarettes, marijuana pipes, or consumed marijuana. Distinctions were also made between weekend and weekday use of marijuana, he says.

"Ever use of marijuana was 66% among controls and 60% among the cases," he says. "Daily marijuana use for a month or more was not associated with increased risk, nor was age at first use, depth of inhalation, or use of a pipe." Surprisingly, using marijuana was not associated with increased cancer risk, even among those who never used tobacco, he says.

During the discussion period after the presentation, several people suggested that lack of quantity may explain why no association was found, because the number of marijuana cigarettes smoked is much lower than the number of tobacco cigarettes smoked. "It is true that we can't really correlate pack-years," says Ford, "and it should be noted that about 30% of the marijuana smokers never smoke cigarettes."

While this study suggests that marijuana has no link to head, neck, and lung cancer, a multicenter study released in March at an American Heart Association meeting linked marijuana use to increased risk of heart attacks. Murray A. Mittleman, MD, PhD, director of cardiovascular epidemiology at Beth Israel-Deaconess Hospital in Boston, told WebMD that marijuana smokers experience a 4.8-fold increase in the relative risk of heart attack during the first hour after smoking. The risk returns to normal after an hour, he said.